Vet antivirus support

In vitro susceptibility testing must depend on cell cultures, which are expensive. More importantly, in vitro inhibitory tests do not necessarily correlate with therapeutic efficacy of antiviral drugs.

Part of the discrepancy between in vitro and in vivo testing occurs because some drugs require activation metabolism to be effective. Only a few antiviral drugs are reasonably safe and effective against a limited number of viral diseases, and most of these have been developed in people.

Few have been studied in animals, and widespread clinical use of antiviral drugs is not common in veterinary medicine. The advent of human immunodeficiency virus HIV and the development of the cat as a model of HIV infection has somewhat increased the animal knowledge base. Only a selection of the more promising agents and their purported attributes are briefly discussed. Most antiviral drugs interfere with viral nucleic acid synthesis or regulation. Other mechanisms of action include interference with viral cell binding or interruption of virus uncoating.

Some viruses contain unique metabolic pathways that serve as a target of drug therapy. Drugs that simply inhibit single steps in the viral replication cycle are virustatic and only temporarily halt viral replication.

Thus, optimal activity of some drugs depends on an adequate host immune response. Some antiviral drugs may enhance the immune system of the host. Dosages of Antiviral Drugs Dosages of Antiviral Drugs The conventional approach to control of viral diseases is to develop effective vaccines, but this is not always possible. The objective of antiviral activity is to eradicate the virus while A variety of pyrimidine nucleosides both halogenated and nonhalogenated effectively inhibit the replication of herpes simplex viruses with limited host-cell toxicity.

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View our extensive database of previously recorded webinars. Antiviral drugs are characterized by a narrow therapeutic margin, meaning that the difference between a dose that is effective and one that causes adverse effects is often small. Treatment is further complicated by viral latency, which is the ability of the virus to incorporate its genome into the host genome. The virus can remain inactive for a long time, then begin reproducing and cause illness again. In vitro susceptibility testing, which is used to tell what drugs a particular virus can be treated with, must depend on cell cultures, and these tests are expensive.

More importantly, these laboratory tests do not necessarily predict which antiviral drugs will work in the animal.

Most antiviral drugs interfere with viral nucleic acid synthesis or regulation. Other mechanisms of action include interference with viral cell binding or interruption of virus uncoating. Some viruses contain unique metabolic pathways that serve as a target of drug treatment.

Drugs that simply inhibit single steps in the viral replication cycle are called virustatic and only temporarily halt viral replication. Thus, optimal activity of some drugs depends on an adequate host immune response. Some antiviral drugs are designed to enhance the immune system of the host.